Nature Methods 2025 年 1 月 22 卷 第 1 期

引言

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Nature Methods 2025 年 1 月 22 卷 第 1 期 文章速递。了解最新前沿科研动态。

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对齐单细胞轨迹
来自两个不同数据集的细胞在时间和空间上对齐的概念可视化。计算机校准正在帮助人类细胞图谱社区创建身体的参考地图，以了解健康和疾病。
Review Articles

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Considerations for building and using integrated single-cell atlases

Brief Communications

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SpatialData: an open and universal data framework for spatial omics

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Vitessce: integrative visualization of multimodal and spatially resolved single-cell data

Articles

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Gene-level alignment of single-cell trajectories

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Evaluation of large language models for discovery of gene set function

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A benchmarked, high-efficiency prime editing platform for multiplexed dropout screening

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EvoAI enables extreme compression and reconstruction of the protein sequence space

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Overcoming the preferred-orientation problem in cryo-EM with self-supervised deep learning

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Global analysis of endogenous protein disorder in cells

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Single-molecule dynamic structural biology with vertically arranged DNA on a fluorescence microscope

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Repurposing large-format microarrays for scalable spatial transcriptomics

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Efficient and highly amplified imaging of nucleic acid targets in cellular and histopathological samples with pSABER

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A foundation model for joint segmentation, detection and recognition of biomedical objects across nine modalities

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Super-resolution imaging of fast morphological dynamics of neurons in behaving animals

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ONIX: a unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior

结尾

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路漫漫其修远兮,吾将上下而求索。
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